Nature Reviews Rheumatology

Engineering approaches for RNA-based and cell-based osteoarthritis therapies

Carlisle R. DeJulius, Bonnie L. Walton, Juan M. Colazo, Richard d’Arcy, Nora Francini, Jonathan M. Brunger & Craig L. Duvall

Intraocular Sustained Release of EPO-R76E Mitigates Glaucoma Pathogenesis by Activating the NRF2/ARE Pathway

Sarah Naguib, Carlisle R. DeJulius, Jon R. Backstrom, Ameer A. Haider, John M. Ang, Andrew M. Boal, David J. Calkins, Craig L. Duvall and Tonia S. Rex

Core polymer optimization of ternary siRNA nanoparticles enhances in vivo safety, pharmacokinetics, and tumor gene silencing

Shrusti S. Patel, Ella N. Hoogenboezem, Fang Yu, Carlisle R. DeJulius, Brock Fletcher, Alex G. Sorets, Fiona K. Cherry, Justin H. Lo, Mariah G. Bezold, Nora Francini, Richard d’Arcy, Jordan E. Brasuell, Rebecca S. Cook, Craig L. Duvall
Nature Biomedical Engineering

Suppression of local inflammation via galectin-anchored indoleamine 2,3-dioxygenase

Evelyn Bracho-Sanchez, Fernanda G. Rocha, Sean K. Bedingfield, Brittany D. Partain, Sabrina L. Macias, Maigan A. Brusko, Juan M. Colazo, Margaret M. Fettis, Shaheen A. Farhadi, Eric Y. Helm, Kevin Koenders, Alexander J. Kwiatkowski, Antonietta Restuccia, Bethsymarie Soto Morales, Arun Wanchoo, Dorina Avram, Kyle D. Allen, Craig L. Duvall, Shannon M. Wallet, Gregory A. Hudalla & Benjamin G. Keselowsky
Advanced Functional Materials

Hybrid Shear-Thinning Hydrogel Integrating Hyaluronic Acid with ROS-Responsive Nanoparticles

Mariah G. Bezold, Andrew R. Hanna, Bryan R. Dollinger, Prarthana Patil, Fang Yu, Craig L. Duvall, Mukesh K. Gupta

Newly Developed Di-Block Copolymer-Based Cell Membrane Stabilizers Protect Mouse Coronary Artery Endothelial Cells against Hypoxia/Reoxygenation Injury

Zhu Li, Mukesh K. Gupta, Matthew B. Barajas, Takuro Oyama, Craig L. Duvall, and Matthias L. Riess
ACS Nano

Nonviral In Vivo Delivery of CRISPR-Cas9 Using Protein-Agnostic, High-Loading Porous Silicon and Polymer Nanoparticles

R. Brock Fletcher, Larry D. Stokes, Isom B. Kelly III, Katelyn M. Henderson, Isabel C. Vallecillo-Viejo, Juan M. Colazo, Benjamin V. Wong, Fang Yu, Richard d’Arcy, Morgan N. Struthers, Brian C. Evans, Jacob Ayers, Matthew Castanon, Michael J. Weirich, Sarah K. Reilly, Shrusti S. Patel, Yoanna I. Ivanova, Carlos A. Silvera Batista, Sharon M. Weiss, Charles A. Gersbach, Jonathan M. Brunger, and Craig L. Duvall
Nature Cell Biology

Microbial small RNAs on LDL promote atherosclerosis-associated inflammation through macrophage TLR8

RM Allen, DL Michell, AB Cavnar, W Zhu, N Makhijani, DL Contreras, CA Raby, EM Semler, C DeJulius, M Castleberry, Y Zhang, M Ramirez-Solano, S Zhao, CL Duvall, AC Doran, Q Sheng, MF Linton, KC Vickers
Journal of the American Chemical Society

A Reactive Oxygen Species-Scavenging ‘Stealth’ Polymer, Poly(thioglycidyl glycerol), Outperforms Poly(ethylene glycol) in Protein Conjugates and Nanocarriers and Enhances Protein Stability to Environmental and Biological Stressors

R d’Arcy, F El Mohtadi, N Francini, CR DeJulius, H Back, A Gennari, M Geven, M Lopez-Cavestany, ZY Turhan, F Yu, JB Lee, MR King, L Kagan, CL Duvall, N Tirelli
Molecular Reproduction and Development

Nanoparticle-mediated transgene expression of insulin-like growth factor 1 in the growth restricted guinea pig placenta increases placenta nutrient transporter expression and fetal glucose concentrations

RL Wilson, K Lampe, MK Gupta, CL Duvall, HN Jones
ACS Chemical Biology

Discovery of a Redox-Activatable Chemical Probe for Detection of Cyclooxygenase-2 in Cells and Animals

MJ Uddin, JH Lo, CG Oltman, BC Crews, T Huda, J Liu, PJ Kingsley, S Lin, M Milad, AM Aleem, A Asaduzzaman, JO McIntyre, CL Duvall, LJ Marnett
Science Translational Medicine

ROS-Degradable Polythioketal Urethane Foam Dressings to Promote Porcine Skin Wound Repair

P Patil, KA Russo, JT McCune, AC Pollins, MA Cottam, BR Dollinger, CR DeJulius, MK Gupta, R D’Arcy, JM Colazo, F Yu, MG Bezold, JR Martin, NL Cardwell, JM Davidson, CM Thompson, A Barbul, AM Hasty, SA Guelcher, CL Duvall
Biophysical Journal

Visualizing the lipid dynamics role in infrared neural stimulation using stimulated Raman scattering

WR Adams, R Gautam, A Locke, Masson LE, AI Borrachero-Conejo, B Dollinger†, GA Throckmorton, CL Duvall, ED Jansen, A Mahadevan-Jansen
Cellular and Molecular Bioengineering

Albumin-Binding Aptamer Chimeras for Improved siRNA Bioavailability

JC Rosch, EN Hoogenboezem, AG Sorets, CL Duvall*, ES Lippmann*
JCI Insight

Therapeutic MK2 Inhibition Blocks Pathological Vascular Smooth Muscle Cell Phenotype Switch

JW Tierney, BC Evans, J Cheung-Flynn, B Wang, JM Colazo, ME Polcz, RS Cook, CM Brophy, CL Duvall.
Nature Biomedical Engineering

Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage

SK Bedingfield, JM Colazo, F Yu, DD Liu, MA Jackson, LE Himmel, H Cho, LJ Crofford, KA Hasty, CL Duvall
ACS Nano

Top-Down Fabricated microPlates for Prolonged, Intra-articular Matrix Metalloproteinase 13 siRNA Nanocarrier Delivery to Reduce Post-traumatic Osteoarthritis

SK Bedingfield, JM Colazo, M Di Francesco, F Yu, DD Liu, V Di Francesco, LE Himmel, MK Gupta, H Cho, KA Hasty, P Decuzzi, CL Duvall
ACS Applied Materials and Interfaces

Shape-Defined microPlates for the Sustained Intra-articular Release of Dexamethasone in the Management of Overload-Induced Osteoarthritis

M Di Francesco, SK Bedingfield, V Di Francesco, JM Colazo, F Yu, L Ceseracciu, E Bellotti, D Di Mascolo, M Ferreira, LE Himmel, CL Duvall*, P Decuzzi*

Settable Polymeric Autograft Extenders in a Rabbit Radius Model of Bone Formation

LA Boller, MA McGough, SM Shiels, CL Duvall, JC Wenke, SA Guelcher
Acta Biomaterials

Effects of nanocrystalline hydroxyapatite concentration and skeletal site on bone and cartilage formation in rats

LA Boller, SM Shiels, DC Florian, SH Peck, JG Schoenecker, CL Duvall, JC Wenke, SA Guelcher
Bioconjugate Chemistry

Optimizing an Antioxidant TEMPO Copolymer for Reactive Oxygen Species Scavenging and Anti-Inflammatory Effects in Vivo

CR DeJulius, BR Dollinger, TE Kavanaugh, E Dailing, F Yu, S Gulati, A Miskalis, C Zhang, J Uddin, S Dikalov, CL Duvall
Acta Biomaterials

Hydrogel microspheres for spatiotemporally controlled delivery of RNA and silencing gene expression within scaffold-free tissue engineered constructs

A McMillan, MK Nguyen, CT Huynh, SM Sarett, G Peilin, M Chetverikova, K Nguyen, D Grosh, CL Duvall, E Alsberg
Journal of Controlled Release

Microsphere antioxidant and sustained erythropoietin-R76E release functions cooperate to reduce traumatic optic neuropathy

CR DeJulius, A Bernardo-Colón, S.Naguib, JR Backstrom, T.Kavanaugh, MK.Gupta, CL Duvall*, TS Rex
Advanced Therapeutics

Recent Advances in Clinical Translation of Intra‐Articular Osteoarthritis Drug Delivery Systems

CR DeJulius, S Gulati, KA Hasty, LJ Crofford, CL Duvall
Scientific Reports

A novel method for visualizing and tracking endogenous mRNA in a specific cell population in pathological neovascularization

MI Uddin, TC Kilburn, CL Duvall, JS Penn